| Title | [Evolution of antimicrobials resistance against Pseudomonas aeruginosa in a French University Hospital between 2002 and 2006.] | | Author(s) | Minchella A, Molinari L, Alonso S, Bouziges N, Sotto A, Lavigne JP | | Institution | Service des maladies infectieuses et tropicales, groupe hospitalo-universitaire de Carémeau, place du Professeur-Robert-Debré, 30029 Nîmes cedex 9, France. | | Source | Pathol Biol (Paris) 2009 Oct 27. | | Abstract | AIM OF STUDY: Monitor evolution of antibiotic resistance of Pseudomonas aeruginosa from 2002 to 2006 in our hospital to optimize antibiotherapy. PATIENTS AND
METHOD: The infections/colonizations with P. aeruginosa have been identified by the hospital's informatic database. Bacteriological samples realized 48hours after patient's admission was considered as nosocomial. A Cochran-Armitage test was conducted to assess the evolution of resistance.
RESULTS: During this period, 2098 infections/colonizations with P. aeruginosa have been identified. Bacteriological samples (68.5%) were nosocomial. Among the beta-lactam antibiotics, ceftazidime and imipenem were the most active (R=16.8% and 15.2%, respectively), followed by piperacillin and piperacillin-tazobactam (R=24.8%, 18.4%, respectively). Amikacin and tobramycin were more active than gentamicin (R=19.9%; 22.2% and 40.6%, respectively). 28.9% of strains were resistant to ciprofloxacin. Nosocomial strains were significantly more resistant than non-hospital strains: ceftazidime: 17.9% versus 14.2%, p=0.0346; ticarcillin-clavulanic acid: 47.5% versus 39.6%, p=0.0009; piperacillin-tazobactam: 20.0% versus 14.8%, p=0.0046; ciprofloxacin: 30.7% versus 25.2%, p=0.0112. A significant increase in the resistance of nosocomial strains to ceftazidime, ticarcillin-clavulanic acid and piperacillin-tazobactam was noted. Resistance from non-hospital strains to fluoroquinolones, aminoglycosides, ceftazidime, piperacillin and ticarcillin-clavulanic acid decreased significantly.
CONCLUSION: P. aeruginosa is a predominantly nosocomial microorganism. There is a decrease of resistance for non-hospital strains. But the resistance of nosocomial strains to antibiotics widely prescribed in hospital is worrying. | | Language | FRE | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19875241 |
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